When consumers look at the cost of drug research, they don’t often consider the complexities that go on behind the scenes. Fees involved with testing, maintenance and licensing compound the costs of a drug at the counter. One example is the turnaround, a technical term for upgrading a factory. Facilities have to shut down for repairs and upgrades, and experiments don’t stop when this happens. A lab relocation
has to carefully handle the experiments in progress, an extremely precise operation. Small costs like this add up over decades for a price tag in the millions (or even billions).
If you’re interested in what drives the cost of medical drugs, read on for some of the major contributing factors.
Length of Time
A clinical trial can take several years to complete, requiring millions in investment to pay for the basic costs. Trials can require all sorts of new equipment, staffing and the costs of running a lab full time. Multiply those costs over a decade’s worth of time and the costs of a drug begin to climb drastically.
The time factor is important because society needs a full understanding of the effects of a drug, and sometimes those effects may not manifest for years. Apharmaceutical test consists of many phases as well. Pre-clinical and clinical can both take 5-7 years to complete, on average.
Cost of Failure
One of the major reasons that drug costs are increasing is that there is a high cost of failure. Very few of the drugs tested will actually make it to market, and those that do will need to recoup a cost numbering into the billions at times. This can seem unrealistic, but the amount of testing required defers the opportunity to profit off a drug by more than a decade, which is a dramatic investment for any company.
Part of the challenge is meeting regulations involved in the safe manufacturing of drugs, but a failed trial can impact a company in other ways. Any company losing up to $1 billion in a failure sees a plummeting stock price and faces serious downsizing.
Part of the big contributor to the cost of research is in sample size. Early-stage testing looks primarily at animals, but as trials progress, they require human volunteers. Early trials look only at dosages to test toxicity, but later stage trials require patients exhibiting certain symptoms. Those volunteers can be hard to find and may add to the expense of data collection.
Even the most efficient trials take several years to complete, requiring many volunteers and staff along the way.
There are several reasons why the costs of a prescription drug may be high other than the major ones cited above. For example, funding for a trial may dry up and require a suspension. A suspension means an experiment will go into storage or may be moved. Things never stop, they just get delayed until the next source of funding is found, now with the added cost of storage.
The costs of a prescription drug are varied, and the returns can be difficult to judge from a consumer or regulatory standpoint. The line is very obscured. It’s clear that more testing leads to a morereliable drug, but more must be done to try and lower or control some of the costs associated with pharmaceutical drugs.
Freezing is one of the oldest way of preserving food, The freezer is the most important part or extension of the pantry which is used to reach out for ice cubes and store much more than just raw meat, icy treats or casseroles. Freezing if done correctly, keeping some principles in mind, is one of the best ways to ensure that excess food can be store for use later. This gives the comfort of a stocked larder. Some points to keep in mind while freezing food are:
Freeze only food you are sure is safe to be frozen and consumed later
Cool all food before freezing
Never refreeze after thawing
Wrap food properly before freezing and label correctly
If these principles are followed then fruits and vegetables can be frozen for a year, poultry up to nine months, fish up to six months, and ground meat up to four months thus helping you save money.
Let’s take a look at foods that we can and should freeze:
CORN ON THE COB: Fresh corn along with the husk and the silk can be packed into freezer bags and frozen till further use. This way it will last for almost a year. Corn can also be husked and blanched and then packed into freezer bags and frozen. This way it will eliminate the taste of the cob if you do not like it.
RAW EGGS: Raw eggs can be stored for at least one month in the freezer but not in their shells. When whole eggs are frozen, the liquid will expand causing the egg shells to crack and seep all-over your freezer. Freeze eggs in cube trays and store in plastic freezer bags for six months. To freeze only yolks add a pinch of salt while beating them prior to freezing.
TORTILLAS: Tortillas can be frozen to store as long as you let them thaw fully in the fridge before use.
POTATO CHIPS: Freeze all leftover potato chips. You can eat them straight from the freezer as cold chips are crispier.
WHIPPED CREAM: Spoon dollops of sweetened freshly whipped cream on a cookie sheet and freeze. Store in freezer containers and they will last a month or two
GARLIC: Garlic can be frozen whole or chopped but always remember to freeze it in oil to avoid botulism. This way it can be stored for months
HUMMUS: Hummus is a very healthy and nutrition packed treat that freezes very well. Always remember to freeze it in an airtight container with lots of Olive oil brimming at the top. This way there is no moisture loss and its stays fresh and tasty for three to four months.
PANCAKES: Extra pancakes can be whipped and prepared and frozen to be used later. Placing wax papers between them and wrapping the stack in a foil paper, will ensure that they stay tasty even after 2 months
FRESH LIME: Fresh lime can be frozen by cutting them to thin slices. Use wax paper between each layer of slices and freeze; ensure all seeds are removed while slicing. Lime juice can be preserved in glass containers. Ensure to leave head space for the liquid to expand.
ONIONS: Whole onions can be saved without freezing. Chopping and dicing onions is always the most mundane chore. It would be wonderful if this could be a onetime chore and then the rest of the week you have ready to be used diced onions available. Diced onions can be saved in freezer bags. Do not thaw when required just toss them into the pan when required.
STEEL CUT OATS: Steel cut oats can be cooked over the weekend and saved in individual glass or one portion containers to be used during the week as required.
AVOCADOS: Avocados are not required to be saved in the freezer but they work great when stored too. Puree the flesh of the avocados with lime juice and store in freezer to be used later for smoothies, dressings or the all-time favourite guacamole.
MUSHROOMS: Mushrooms can be saved cooked and cooled to room temperature or raw chopped and sliced. Freeze on cookie sheets to keep them separate and prevent them from clumping or crumping. Once frozen they can be transferred to freezer bags and saved.
BREAD: Sliced bread remains for about 3 months when stored in the freezer and can be revived quickly in the toaster. This makes the freezer a better option for bread than the fridge.
GRAINS: Grains like quinoa, farro and bulgur last for about three months outside the freezer. But when frozen they last up to six months
GINGER: Peel and save ginger in freezer bags to be used later.
TOMATO PASTE: Tomato paste can be frozen in small spoonful portions and saved for later use.
HERBS: Expensive herbs can be bought when cheap, chopped and stored with olive oil in ice trays for use later.
SHREDDED CHICKEN: Shredded chicken can be stored in batches. it is always available and handy to use
LEFTOVERS – never throw away the leftovers from a meal or from a cooking:
COOKED RICE AND PASTA – can be frozen for a second meal later
MASHED POTATOES – can be portioned with an ice-cream scoop and frozen in freezer bags for about 2 months.
PIE – freeze remaining pie portions. These can be amazing midnight snacks or can be added to churn our yummy shakes.
FROSTING – frosting can be saved in freezer Ziploc bags in a very easy way. ?they are ready to be used anytime by just cutting away a little corner of the bag and squeezing.
This list is endless. We can still experiment and make this inexhaustible. So the next time you plan to throw away any leftovers from your cooking or excess purchases for the month, please sit back and think for a while if there is a way to freeze it and use later. Happy Freezing!
Just a few decades ago, the concept of a smart home didn’t even exist, but innovative technological advancea and accomplished feats of engineering now mean that the option to protect our homes with advanced security and safety features is becoming far more accessible.
Knowing your home is secure and protected can be hugely comforting, and whether you want to ensure your home is warm for when you get home, keep a watchful eye on your pets, or switch on your security lighting system, home automation systems are becoming more integrated into our daily lives with each passing year.
Selecting your system
With home automation companies, such as Digital Interiors (http://digitalinteriors.co.uk), producing a variety of different products, selecting the right system for your needs can seem like an overwhelming task. However, ensuring you fully understand the features you require will ensure the process isn’t as daunting as initial impressions may suggest.
When thinking about protecting your home, keeping intruders away from your premises is likely to be at the top of your list. Smart technology is now capable of sending an alert directly to your smartphone when windows are opened unexpectedly or doors are damaged, alleviating concerns when you’re away from home.
Protecting your home with surveillance cameras can also provide additional peace of mind, ensuring that there are no potential intruders lurking around your property looking for possible areas of entry.
Alerting the emergency services
As this article indicates, gas leaks, flooding, and fires are all serious concerns for homeowners. Advanced security systems will immediately alert the relevant emergency services should an issue be detected, potentially saving your home, your possessions, and even your life in the process.
Controlling your thermostat, turning lights on or off, or drawing the curtains while you’re away from home may seem like a bit of a luxury, but these simple functions can also boost the security of your home, creating the illusion of someone being inside even if you’re stuck in traffic or you have had to change your plans at the last minute and need to leave your home unattended.
It’s always good to start a business and live an independent life. However, you need to keep a lot of things in mind while doing so in order to avoid any last moment hassle. In case you are a medical practitioner and planning to setup a clinic in your city, then make sure you take necessary steps in such a way that things can be executed comfortably. Here is how you can forge ahead in this direction-
Research About Local Requirement
Even before you start the business, spend some time in researching to know what customers want from healthcare clinics in your area and which all products sell the most. Though the research may take some time and require you to think out of the box, when you complete it successfully, you can see some amazing insights that will help you in an amazing way.
Have Necessary Equipment In Place
Just because you are starting afresh doesn’t mean you can afford not to have all the equipment required to treat patients adequately. Remember, people will come to you only when they realize that you have everything available in-house and they won’t have to look for an alternative option again. So, leave no stone unturned when it comes to buying necessary tools and equipment for your business.
What you can do is give a shot at refurbished medical equipment in case you’re short of money in the beginning and haven’t yet started getting a huge demand from customers. There are quite a few companies that provide both used and new healthcare equipment at affordable prices, so you don’t have to face any trouble while trying to buy high-quality equipment for your clinic.
Once these two are done, you can forge ahead and focus on recruiting staff members who are dedicated to serving customers to the best of their abilities. These three things should be kept in mind whenever someone decides to start a new healthcare clinic. If you want to succeed, you can pay attention to them and have a great experience overall.
Winter wear online is the best option for you so that you can get warm clothing for keeping you warm and comfortable during winters and the most popular winter wear is women jackets that are experiencing a surge in demands with the onset of winters. Jackets for women offer you the opportunity of getting a kind of clothing that you need to face the cold winters with style, warmth and comfort so that you can look elegant and ravishing. Thus you will need to look for women jackets that are available in different materials, styles, shapes and colors so that you can select the one that will suit your requirements. Leather jackets for ladies are known for its boldness and beauty that it offers to girls because these stylish jackets can accentuate the look of the girl as it is available in many trendy colors for complementing any dress. Moreover leather jackets are loved by girls and women alike as it has the style and warmth factor that they are looking for in the winter wear. Jackets for women are gaining popularity because it can be worn with any outfit as it offers amazing confidence when you wear this winter wear for everyday use or any special occasion. Thus it can also be called as a wardrobe essential that you need as women jackets can give flair to any outfit without putting in a lot of efforts. Leather jackets for girls are suited for everyday use in the winter as it offers warmth to the body as it is a fashionable and versatile jackets that can enhance your look instantly. Jackets are getting a lot of attention by women of every age, size and body style as you can wear this jacket for making your fashion statement and expressing your style and personality. Winter wear for girls means look for clothing that will offer warmth and make you look stylish as these are winter appropriate clothing that is an excellent addition to your wardrobe. You can feel cozy and look sassy when you buy high quality leather jackets that have been especially designed for women who want to follow the latest fashion trends as there are many options so that you can be spoilt for choice. Leather jackets are always in high demand in the winter months which makes it even more important to consider buying a stylish and elegant jackets for women at https://www.stalkbuylove.com/women-jackets/ and enjoy easy and reliable shopping.
It has become the common trend among corporate houses to offer amazing gifts to their business clients and friends in order to form a strong business relationship for a lifetime. These corporate gifts are also helpful in improving the overall image and reputation of your company in a seamless manner. If you are looking to build the effective business engagement with your clients around the world, you need to offer these wonderful corporate gifts without any delay.
Offer them a stress buster gift or healing gift- The competition in a business environment is very ruthless and tiring. If you want to offer a soothing and trouble free environment to your corporate clients, you need to gift them a spa kit, aroma oil therapy kit, Feng Shui items or any other presents that can have a positive impact on their mind. You can easily send these wonderful items as corporate gifts to India and abroad for your business clients.
Order a fitness band or any other gift for them- It is very difficult to maintain your fitness levels due to tight business schedules and appointments. In order to help your business clients achieve a certain level of fitness, you need to offer them a fitness band or any other gift item that can help in monitoring their fitness levels and important body functions.
Choose a basket or hamper of healthy snacks- If you want to offer exceptional gifts for businessmen that can be remembered for a long time, you need to offer them healthy snacks option. You can order digestive snacks, high fibre cookies, dry fruits, green tea, dark chocolates and other such food items that can help in fighting those odd time hunger pangs in a seamless manner.
Buy personal care hamper- In order to boost your business engagement with your clients, you need to order personal care hamper comprising of a tie, leather belt, cologne, pocket square, brooch/cufflinks and other items that can help in improving the personality of your business client.
Offer them an office décor item- We all want our office space to look good and well maintained. In order to help out your business clients, you can order a wide range of office décor items from any corporate gifting companiessuch as table tops, indoor plants, pen holder stands, folders and other gifts in an effortless manner.
Choose any electronic gift items- If you are short of gift ideas for your corporate clients; you need to offer them amazing electronic gift items such as a USB storage device, Bluetooth speaker or any other gift item that can effortlessly capture the attention of your business clients.
It is time to order these fantastic corporate gifts to India and abroad through any available corporate gifting companies in order to improve the reputation and brand value of your company.
Breakfast in bed must be up there as one of the best ways to start your day. No jumping out of bed at the first sound of an alarm clock, no dashing to work with only a slice of cold toast for sustenance – quite simply, you have nowhere to be.
Now the days are colder and shorter, it’s even more tempting to stay beneath the covers, so follow our top tips for the perfect breakfast under the duvet.
What You’ll Need
The key to a great breakfast in bed for yourself or a loved one is organisation. That doesn’t sound particularly relaxing or indulgent, but a few key items will make all the difference. You’ll need a tray large enough to hold everything, cutlery to eat with and napkins to catch the crumbs. Flowers are optional but add a nice touch.
Where You’ll Be
Of course, you can enjoy breakfast in bed in the comfort of your own home, but why not make the most of it and whisk yourself off to a luxurious hotel or stylish boutique apartment such as no. 8 Waterloo Street apartments, which will afford you all the privacy of home? The beauty of venues like these Birmingham serviced apartments is that they are like a home from home, complete with fully equipped kitchen and sumptuous surroundings, but you won’t have to do the clearing up.
Thankfully, the nation’s best-loved chefs all have their own take on the perfect way to indulge in this favourite leisurely pastime, continually creating an array of mouth-watering recipes. From Angela Nilsen’s healthier take on the full English to James Martin’s Spiced Bloody Marys, there’s no shortage of delicious ideas. Why not try your hand at one of the recipes, or even better get someone else to try them for you?
You don’t need to be a culinary master either. Dip delicious pancetta-wrapped avocado into your soft boiled egg, or add nutritious matcha powder and maple syrup to some natural yoghurt. Top with kiwi, peach, blueberries and coconut flakes – delicious yet simple.
So now that we’ve provided you with all the ingredients for a fabulously lazy breakfast in bed, there’s no excuse. Choose your venue, stock your fridge and hit the snooze button as you snuggle down under the duvet for some you time.
If you want to be able to watch your favorite movie anytime, anywhere, jump onto one of the most popular sites, Putlockers movie 2016, and watch them. Watching movies online is the trend. It has made watching movies easy and accessible so you should be able to get the best out of it.
Watching movies online is as easy as A-B-C. However, to maximize your viewing you need to know that there are several other steps to make other than the simple basic ones. This will ensure that you are safe and that you get to enjoy without fear.
Before everything else, you need to do is to watch out for those torrents. Torrents seem to be accessible but they bring the most infection to your computer. Most torrents contain viruses and spyware. These infection that they carry along are not even scared of anti-virus software. Those anti-virus will simply not work on them.
Instead of going to those torrent sites, go to those paid ones. The price is not relatively too big and it is cost efficient because you get to enjoy unlimited viewing only for a one time pay. Plus, you can even download some of them.
So finally you can pay and subscribe to the online movie site of your choice. But before doing so, you also need to check a few things. Before making that payment, make sure the site offers a money back guarantee. You will not be sure about the services that online sites offer and the only way to make sure you don’t get scammed is by also making sure they have a money back guarantee.
To be sure that you also get your money’s worth, make sure that the online site you are subscribing to does not only offer movies but TV shows and music as well. When you are subscribing, make sure you get the most out of the subscription. So choose an online site that offers unlimited movies, unlimited TV shows and music.
There are also sites that not only show movies but feature movie trailers and interviews. These sites are also good for the money. You get to enjoy your money’s worth.
When you have found a site that has all these, then you are sure that is a good online movie site. You can be confident to give out your credit card details and subscribe. Then start enjoying what you deserve.
What used to be disregarded as conspiracy theories is now plain fact; Your government is spying on you. Since the evidence of mass spying from the government came to the light, people have come to the sad realization that they’re being watched and listened to at every turn. Phones, laptops, PCs, corporate servers, TVs, social media and cloud accounts and so much more are all within reach of the government. Basically, your entire digital life is being monitored despite assurances from companies that their tech is secure.
While this has forced people into a paranoid awakening, it has also brought forth an intellectual desire for cybersecurity. More people are now concerned about what they can do to protect themselves against this illegal intrusion into their lives. Taking active steps to safeguard your privacy is the best option, but how exactly should one go about doing that?
Invest in a premium VPN
I consider VPNs to be a much-needed ray of light in an otherwise dark digital reality. One of the greatest vulnerabilities that are exploited by the government, is unsecured networks. The internet allows you to send packets of data from one location to the other, through a designated network. For this to be possible, your device is assigned a unique address, known as the IP address, to allow your device to connect to the internet. Therefore, if anyone gained access to your IP address they could track down your physical address as well as easily manipulate the data packets sent through that IP. The KRACK attack has also proven that seemingly secure networks are compromised by exploiting WPA2 vulnerabilities. Relying on a password for security and relaxing because you assume the network is encrypted is no longer a safe option. However, this all changes with a VPN, so what is a VPN? A VPN encrypts your network, and all the data sent through your device, assigns your device a different IP, and sends your data through an encrypted network. Think of it as a force field that shields your entire network. This effectively cuts out the ability of the government to spy on you or at least makes it very difficult for them to.
Basically, the government is able to digitally spy on us because our connection to the internet gives them a direct line to access. Using a VPN is an effective solution for this, but there is always the risk that the VPN could be hacked. Air gapping presents a great solution with less risk. Air gapping is the isolation of your network and devices from unsecured public networks such as the internet. This is more or less like creating your very own secure and private network. Your devices would still manage to access the public internet by using secure ports, but there would be no way to access your network or devices from the outside. The transfer of data back and forth would be tedious but it is well worth it.
Minimize your digital footprint
They say, “The internet never forgets” and this is true both literally and figuratively. Each time you log onto and use the internet, you leave a digital trace. Since each person’s digital footprint is unique, it can easily be used against you. By tracing few bits of your digital footprint, the government can then use powerful algorithms to find similar traces of information on the internet. Correlating the data would then allow them access to everything from your social media accounts to financial details. Unfortunately for us, even deleting that information online is ineffective since the information will always exist deep in the internet as code. The best way to avoid being spied on is by reducing this print, thereby affecting their ability to correlate the data they are able to get. For instance, sharing less personal data on social media can be very helpful in reducing your print.
Install firewall and antivirus software
All these measures to safeguard your network and digital identity are useless if the government has direct access to your devices. Malware in your device could be used to send out information without your knowledge. In fact, this is one of the best techniques that the government uses in the surveillance effort. Firewall software creates a shield that controls how and why your device connects to the internet. This makes it ideal for protecting your devices from outside intrusions. Antivirus software plays an even more comprehensive role in safeguarding your devices. Aside from duties similar to firewalls, an antivirus is also effective in identifying threats and purging them from your system. Both the antivirus and firewall should work to ensure that no malware is installed on your device.
Update your devices
There are no flawless systems or devices out on the market. The government has been using flaws in the operating systems of most devices to run surveillance ring on us. Consider, for instance, the hack by the CIA into Apple, which exposed a potential half a billion users to illegal surveillance. Most developers expect there to be flaws but they also expect those who find those flaws to report them so they can be fixed. Eventually, the developers always find such flaws in their systems and fix them in system and security updates, thereby eliminating the risk. This is why you need to constantly update your devices. Ensuring that your device runs on the most recent firmware is an easy way of avoiding government surveillance.
Cover your webcam and microphone
This is a very low-tech move that involves tape. Hackers can use the webcam to watch you and the microphone to listen to you without your knowledge. By covering up both of them with tape, you ensure that you maintain some level of your privacy. This is a failsafe because you can never be too sure that your system is clean, even though your antivirus and firewall say so. Government hackers have found ways of circumventing security measures such as antivirus and firewall software.
Avoiding government surveillance is a lot about expecting the worst from them. Paranoia spikes a desire for research and innovation, which could very well help you maintain your privacy. You need to use everything at your disposal from VPNs to taping your webcam. The truth is, even with your best effort you might still find that you are under surveillance. Nevertheless, you will have made it increasingly difficult to spy on you and they might determine that you are not worth the effort.
In the millennial world, internet becomes one of the necessities that millennial people needs, basically everything could be searched and found on the web in a snap. Meanwhile, online world makes the present situation an easier place to live in, though for some it may still be a luxury that could not be accessed easily; for there are still places that is not yet reached by internet and people in these places are deprived of the privilege the millennial time offers.
The web nowadays offer users the broad knowledge the internet could provide; from searching meanings of a certain word, picture, instructions, and even videos of various things that one may ask for. Videos that are featured in the internet may include tutorials, blogs and even short movies. For convenience purposes, these videos are uploaded by the users, it may be for fun, for information or just for the sake of sharing. Sharing everything in the net is just another ordinary gesture that anyone can do now, from facebook, instagram, youtube and etc. it is a free world after all.
Sharing 123movies online is one of the breakthroughs of the internet world, and some sites share movies for free or for a fee. It is very usual in the present time to find free and watch movies online, some of it may include video blogs that are usually made by individual persons, for fun and for information; on the other hand, some websites ask for a fee for a certain movie and some may even ask for a membership or subscription so you can access their site and watch movies online.
Anybody can watch movies online just by searching the net using specific titles, words, or choose from different movie choices that the search engine could ever find. There are also different ways to share various videos or movies online, these pieces could be uploaded via website or page that are readily available to watch anytime. Another way to watch movies online is via shared links of a specific site which could also be shared by copying the link and pasting it anywhere you can, like a blog, a page or even in an article.
So it is up to an individual to find something in the net, may it be for a fee or for free.